Neomycin, Isoflupredone, and Tetracaine: Topical

What is neomycin, isoflupredone, and tetracaine?

Neomycin, isoflupredone, and tetracaine (brand names Neo-Predef with Tetracaine®, Tritop®) is a combination antibiotic (neomycin), steroid (isoflupredone), and local anesthetic (tetracaine) used in the treatment of certain superficial infections. It is labeled for use in cats, dogs, and horses to treat certain types of skin and ear infections.

It may be used “off label” or “extra label” to treat other conditions or in other species. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully.

How do I give my pet neomycin, isoflupredone, and tetracaine powder?

Neomycin, isoflupredone, and tetracaine comes as a powder and an ointment meant to be applied directly on the skin (topically).
Clean the affected area as directed by your veterinarian before applying the medication.
Do not allow the tip of the bottle or tube to touch affected areas.
Wash your hands after application and avoid contact with eyes, mouth, and nose.
Do not allow your pet to lick or chew the affected area.
Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears your pet is feeling better.

What if I miss giving my pet the medication?

Give the missed dose as soon as you remember and then continue with the regular dosing schedule. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give the pet two doses at once.

Are there any potential side effects from neomycin, isoflupredone, and tetracaine?

Neomycin, isoflupredone, and tetracaine topical treatments may cause the following side effects:

redness and/or swelling at site of application
thinning of fur or fur loss
decreased energy level or appetite, vomiting, diarrhea
sores around the mouth
increased thirst

The following reactions are rare, but if they occur, contact your veterinarian immediately:

an allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This moderate-acting medication should stop working within a few days but may take longer in pets with kidney or liver disease.

Are there any risk factors for this medication?

This medication should be AVOIDED in pets who:

are allergic to any component
have tuberculosis skin infections
have ruptured ear drums

This medication should be used with CAUTION when treating:

pets with small body size
large areas on the body
dogs in any stage of pregnancy
cats and horses in later stages of pregnancy

Are there any drug interactions I should be aware of?

No known drug interactions have been reported for this combination medication, though certain medications may interact with the individual drugs of this combination medication.

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

Your veterinarian may schedule a follow-up visit for after the course of medication is complete to ensure the infection has been cleared and/or do additional testing to ensure this is the right medication for the type of infection that is present. In this case, follow your veterinarian’s directions.

How do I store topical neomycin, isoflupredone, and tetracaine?

Store the medication in its original container, protected from moisture, at room temperature.
Keep the cap tightly closed.
Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.